Cultivation of previously uncultured microorganisms with a continuous-flow down-flow hanging sponge (DHS) bioreactor, using a syntrophic archaeon culture obtained from deep marine sediment as a case study

Hiroyuki Imachi, Masaru K. Nobu, Masayuki Miyazaki, Eiji Tasumi, Yumi Saito, Sanae Sakai, Miyuki Ogawara, Akiyoshi Ohashi, Ken Takai

Published: 2022-09-13 DOI: 10.1038/s41596-022-00735-1

down-flow hanging sponge bioreactor

uncultured microorganisms

syntrophic archaeon

deep marine sediment

anaerobic incubation

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In microbiology, cultivation is a central approach for uncovering novel physiology, ecology, and evolution of microorganisms, but conventional methods have left many microorganisms found in nature uncultured. To overcome the limitations of traditional met
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ACKNOWLEDGMENTS

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Cultivation of previously uncultured microorganisms with a continuous-flow down-flow hanging sponge (DHS) bioreactor, using a syntrophic archaeon culture obtained from deep marine sediment as a case study

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