Spatial visualization of comprehensive brain neurotransmitter systems and neuroactive substances by selective in situ chemical derivatization mass spectrometry imaging

Per Svenningsson, Andreas Dannhorn, Richard J. A. Goodwin, Reza Shariatgorji, Anna Nilsson, Elva Fridjonsdottir, Nicole Strittmatter, Luke R. Odell, Per E. Andrén

Published: 2021-06-01 DOI: 10.1038/s41596-021-00538-w

mass spectrometry imaging

neurotransmitter mapping

chemical derivatization

fluoromethylpyridinium

pyrylium reagents

AI 解读

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Molecule-specific techniques such as MALDI and desorption electrospray ionization mass spectrometry imaging enable direct and simultaneous mapping of biomolecules in tissue sections in a single experiment. However, neurotransmitter imaging in the complex
Introduction
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Anticipated results
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ACKNOWLEDGMENTS

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Spatial visualization of comprehensive brain neurotransmitter systems and neuroactive substances by selective in situ chemical derivatization mass spectrometry imaging

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